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Windel Plus Nebuliser Solution 1 Ampoule
Windel Plus Nebuliser Solution combines two active bronchodilators:
- Salbutamol sulfate: A beta2-adrenergic agent that relaxes airway smooth muscle from the trachea to the terminal bronchioles, preventing bronchoconstriction.
- Ipratropium bromide: An anticholinergic compound that inhibits vagally mediated reflexes by antagonizing acetylcholine, preventing bronchial smooth muscle constriction.
Together, these medications provide bronchodilation by acting on both muscarinic and beta2-adrenergic receptors in the airways, with a synergistic effect and minimal systemic side effects.
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✅ Description:
Windel Plus: Each LDPE ampoule contains 3 ml isotonic, clear solution for inhalation of Salbutamol Sulphate BP equivalent to Salbutamol 2.5 mg and Ipratropium Bromide BP equivalent to Ipratropium 0.5 mg.
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✔️ Side Effects
Common side effects include skeletal muscle tremors, nervousness, and less frequently, tachycardia, dizziness, palpitations, or headaches. Serious hypokalemia may result from prolonged high-dose therapy.
✔️ Pharmacology
- Ipratropium Bromide: Rapidly absorbed after inhalation; systemic bioavailability is below 10%. Elimination half-life is 3.6 hours. Does not cross the blood-brain barrier.
- Salbutamol Sulfate: Quickly absorbed after inhalation or oral use; peak plasma concentrations are reached in 3 hours. It has a 4-hour half-life and can cross the blood-brain barrier.
✔️ Dosage
- Adults (including elderly): Use one 3 ml ampoule in a nebulizer four times daily, with up to two additional treatments if needed.
- Children: Dosage must be determined by a physician.
✔️ Administration
- Twist off the ampoule top, holding it upright.
- Squeeze the solution into the nebulizer chamber.
- If necessary, dilute according to the doctor's instructions.
✔️ Interactions
- Concomitant use with beta-mimetics, anticholinergics, or xanthine derivatives may increase side effects.
- Beta-agonist-induced hypokalemia can be exacerbated by diuretics, glucocorticosteroids, and xanthine derivatives.
- Caution with digoxin, as hypokalemia can increase arrhythmia risk.
- Concomitant use of beta-blockers may reduce bronchodilator effects.
- Beta-agonists should be used cautiously with MAO inhibitors or tricyclic antidepressants.
✔️ Contraindications
- Not suitable for patients with hypertrophic obstructive tachyarrhythmia or those allergic to atropine or its derivatives.
✔️ Overdose Effects
Overdose symptoms (mainly from Salbutamol) include tachycardia, chest pain, hypertension, palpitations, and tremors. Treatment involves sedatives or beta-receptor blockers.
✔️ Other side effects include:
- Respiratory: Cough, bronchospasm, local irritation.
- Non-respiratory: Nausea, vomiting, sweating, muscle cramps, arrhythmias.
- Anticholinergic effects: Dry mouth, mydriasis, and urinary retention (rare).
✔️ Pregnancy & Lactation
- Pregnancy Category C: Use only if the benefit justifies the risk. Animal studies have shown the teratogenic effects of Salbutamol.
- Caution during breastfeeding: Salbutamol sulfate and Ipratropium bromide may pass into breast milk, though minimal amounts are expected with inhalation.
✔️ Precautions & Warnings
- Seek medical attention immediately for acute, rapidly worsening dyspnea.
- Rare immediate hypersensitivity reactions include urticaria, angioedema, rash, and bronchospasm.
✔️ Storage Conditions
Store below 30°C, away from light and moisture, and keep out of the reach of children.
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